Assay

Edoxaban

Key Words

Direct Xa inhibitor, Edoxaban

Specimen Collection

3.0ml Citrate (Green lid). 1.4ml Citrate for paediatric (Green lid). Fill to mark. Samples should ideally be received by the laboratory within 3 hours of collection.

Turnaround time

Next working day

Test indications

Edoxaban dose monitoring

Interferences

Edoxaban levels change markedly over time owing to the pharmacokinetics of the drug (e.g. levels of edoxaban will differ greatly 1–3 hours versus 10-14 hours after dosing). Interpret results with caution. Discuss with Consultant Haematologist if necessary.

Reference Range

See table below. Discuss with Consultant Haematologist if necessary.

Minimum retesting interval

N/A

Dose (mg)

Trough (ng/mL)

Peak (ng/mL)

30mg once daily

130-174

376-412

60mg once daily

268-336

388-444