Annals of Clinical Biochemistry, Ahead of Print.
BackgroundFaecal immunochemical tests (FIT) detect and quantify faecal haemoglobin (f-Hb) to triage symptomatic primary care patients for the risk of colorectal cancer (CRC).MethodFIT was performed using FOB Gold® on a Siemens ADVIA Chemistry XPT analyser ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundPneumatic tube systems (PTSs) have revolutionized sample transport efficiency, yet concerns about sample integrity remain unresolved. This study evaluated the AirLab system (PazKorea, Hanam-si, Korea), a novel high-speed carrier-free PTS, for ...

Annals of Clinical Biochemistry, Ahead of Print.
Glycerol kinase deficiency (GKD) is a rare X-linked metabolic disorder often presenting in infancy or childhood. In adults, it may remain undiagnosed due to nonspecific symptoms or incidental biochemical findings. We report a case of incidental GKD ...

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.
Strict homoeostatic control of potassium is necessary for normal muscle and neural function, and as a result, hyperkalaemia can be life-threatening and requires timely management. Prior to treating the patient, however, it is important to determine if ...

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundThe rise in serum thyroid stimulating hormone (TSH) in healthy older adults is well established. However, age-related reference intervals are not widely used. We aimed to establish all-adult and age-related reference intervals for TSH, free ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundSerum copper is an essential trace element, and accurate quantification is important for assessing copper status in pregnancy and supporting early clinical interventions. However, current serum copper assays face several challenges, including ...

Annals of Clinical Biochemistry, Ahead of Print.
ObjectivesTo evaluate the stability of commonly used biomarkers in whole blood under various storage conditions, in order to assess their suitability for home-based blood collection in remote care settings.MethodsWhole blood samples were stored at 4–8°C, ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundLaboratory test results are crucial for clinical decisions, but errors at any stage can compromise patient safety. Despite technological advances and quality systems, laboratory processes remain vulnerable, necessitating structured risk ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundConventional transcutaneous bilirubinometers often underestimate total bilirubin (TB) levels at high concentrations, limiting their clinical utility in cases of neonatal hyperbilirubinemia. We aimed to address this shortcoming by developing and ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundThe foetal anomaly screening (FAS) programme in England screens for trisomies 21, 18 and 13 using a combination of maternal age and biochemical and ultrasound markers in a multivariate Gaussian approach to calculate the chance of a foetal ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundThis study aimed to identify laboratory parameters that could optimize the PLASMIC score, thereby improving its diagnostic accuracy for thrombotic thrombocytopenic purpura (TTP).MethodsWe performed a retrospective analysis of 136 patients with ...

Annals of Clinical Biochemistry, Ahead of Print.
ObjectivesAcidification of urine samples has long been used as a method of preservation to enhance analyte stability. However, there are inherent safety risks to staff and patients when acid preservatives are used. The Association of Laboratory Medicine ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundPhosphatidylethanol (PEth) is formed in erythrocyte membranes after alcohol consumption. When abstaining, the PEth level falls with a rate proportional to its concentration, and a short apparent PEth half-life supports abstinence. We here derive ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundCystatin C (CysC) is a biomarker used to assess kidney function. Produced by all nucleated cells, it is freely filtered by the glomeruli, and its serum levels increase rapidly following kidney injury. Establishing reference intervals (RIs) is ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundMeasurement of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and left ventricular ejection fraction (LVEF) are used in diagnosing heart failure (HF). The main aim was to explore the correlation between NT-proBNP and LVEF.MethodsPatient ...