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Table of Contents for Annals of Clinical Biochemistry. List of articles from both the latest and ahead of print issues.
Updated: 1 hour 42 min ago
Relationships of serum levels of tocilizumab to interleukin-6 and endogenous markers of CYP3A activity in patients with rheumatoid arthritis
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundTocilizumab co-administration and inflammatory conditions potentially alter the activity of cytochrome P450 (CYP) 3A4 by modulating the interleukin-6 (IL-6) signaling pathway in patients with rheumatoid arthritis (RA). This study aimed to ...
BackgroundTocilizumab co-administration and inflammatory conditions potentially alter the activity of cytochrome P450 (CYP) 3A4 by modulating the interleukin-6 (IL-6) signaling pathway in patients with rheumatoid arthritis (RA). This study aimed to ...
Application of ergosterol as a maitake mushroom intake biomarker
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundDyslipidemia is a lifestyle-related disease; therefore, cholesterol biosynthesis inhibitors in foods can be easily ingested on a daily basis and are effective in aiding treatment and prevention. To assess the impact of this diet on health, it is ...
BackgroundDyslipidemia is a lifestyle-related disease; therefore, cholesterol biosynthesis inhibitors in foods can be easily ingested on a daily basis and are effective in aiding treatment and prevention. To assess the impact of this diet on health, it is ...
Diurnal variation in salivary testosterone independent of food consumption
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundWe previously reported that salivary testosterone (Sal T) decreased following a morning meal but concluded that this decrease could be a postprandial effect or an inherent circadian rhythm or both. Since no studies describing diurnal variations ...
BackgroundWe previously reported that salivary testosterone (Sal T) decreased following a morning meal but concluded that this decrease could be a postprandial effect or an inherent circadian rhythm or both. Since no studies describing diurnal variations ...
The influence of haemolysis in patient samples on biochemical tests analysed using Roche Cobas® 8000 analyzer
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundModern analyzers employ the haemolysis index (HI) to identify interference in biochemical assays, yet manufacturer-defined HI thresholds may be inappropriate for true haemolysis effects, resulting in unnecessary sample rejections. This study ...
BackgroundModern analyzers employ the haemolysis index (HI) to identify interference in biochemical assays, yet manufacturer-defined HI thresholds may be inappropriate for true haemolysis effects, resulting in unnecessary sample rejections. This study ...
Clinical profile and utility of biomarkers in children with cobalamin (vitamin B12) deficiency: A cross-sectional study
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundTo assess utility of novel biomarkers in diagnosing children with clinical cobalamin deficiency. Current practice uses total vitamin B12 levels to confirm diagnosis, which lacks sensitivity when used in isolation.MethodsBetween November 2020 and ...
BackgroundTo assess utility of novel biomarkers in diagnosing children with clinical cobalamin deficiency. Current practice uses total vitamin B12 levels to confirm diagnosis, which lacks sensitivity when used in isolation.MethodsBetween November 2020 and ...
Variability in SHBG assays and the effect thereof on calculated estimates of free testosterone
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundSerum free testosterone is commonly used as a parameter to evaluate testosterone exposure and is mostly calculated using mathematical approximations. As the principal testosterone-binding protein, SHBG concentration is always included in such ...
BackgroundSerum free testosterone is commonly used as a parameter to evaluate testosterone exposure and is mostly calculated using mathematical approximations. As the principal testosterone-binding protein, SHBG concentration is always included in such ...
The early diagnostic value of C-reactive protein (CRP) in deep sternal wound infection after cardiac surgery
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundThis study aimed to evaluate the early diagnostic value of C-reactive protein (CRP), procalcitonin (PCT), white blood cell count (WBC), neutrophil ratio (NEUT%), and neutrophil-to-lymphocyte ratio (NLR) in patients with deep sternal wound ...
BackgroundThis study aimed to evaluate the early diagnostic value of C-reactive protein (CRP), procalcitonin (PCT), white blood cell count (WBC), neutrophil ratio (NEUT%), and neutrophil-to-lymphocyte ratio (NLR) in patients with deep sternal wound ...
Sweat testing and cystic fibrosis – Test performance before and after a quality improvement project in a South African tertiary hospital laboratory
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundThe diagnosis of cystic fibrosis (CF) is challenging due to high quantity not sufficient (QNS) rates of sweat tests, leading to frequent retesting, increasing costs and adverse impacts on patient care. This study aimed to assess sweat test ...
BackgroundThe diagnosis of cystic fibrosis (CF) is challenging due to high quantity not sufficient (QNS) rates of sweat tests, leading to frequent retesting, increasing costs and adverse impacts on patient care. This study aimed to assess sweat test ...
Application of the six sigma model to evaluate the analytical performance of serum lipid analytes and design quality control strategies: A multi-centre study
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundThe six sigma model is widely used in laboratory quality management. For the first time, this study introduced total allowable error (TEa) from WS/T403-2024 and ‘desirable’ biological variation (BV) as dual quality goals to evaluate serum lipid ...
BackgroundThe six sigma model is widely used in laboratory quality management. For the first time, this study introduced total allowable error (TEa) from WS/T403-2024 and ‘desirable’ biological variation (BV) as dual quality goals to evaluate serum lipid ...
Detection of urinary SERPINA4 by electrochemiluminescence immunoassay and development of a diagnostic model for diabetic nephropathy
Annals of Clinical Biochemistry, Ahead of Print.
Background and objectivesSERPINA4 has been identified as a potential diagnostic biomarker for diabetic nephropathy (DN) in our previous research. This study aims to develop electrochemiluminescence immunoassay (ECLIA) methods for the detection of SERPINA4 ...
Background and objectivesSERPINA4 has been identified as a potential diagnostic biomarker for diabetic nephropathy (DN) in our previous research. This study aims to develop electrochemiluminescence immunoassay (ECLIA) methods for the detection of SERPINA4 ...
Is there utility in testing IgA-endomysial antibodies in patients with weak-positive or equivocal IgA-tissue transglutaminase antibodies in the diagnosis of coeliac disease? A critique of current NICE guidance (NG20)
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundCurrent coeliac disease (CD) NICE guidelines recommend testing IgA-endomysial antibodies (EMA) following a weak-positive IgA-tissue transglutaminase antibody (tTGA). Outside of patients with very high IgA-tTGA results, a positive IgA-EMA ...
BackgroundCurrent coeliac disease (CD) NICE guidelines recommend testing IgA-endomysial antibodies (EMA) following a weak-positive IgA-tissue transglutaminase antibody (tTGA). Outside of patients with very high IgA-tTGA results, a positive IgA-EMA ...
Thank you to our reviewers
Annals of Clinical Biochemistry, Volume 62, Issue 3, Page 224-225, May 2025.
Pseudohyperphosphatemia induced by endogenous lipoproteins: New elements supporting an interference with ammonium phosphomolybdate-based methods
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundInorganic phosphate (Pi) is a crucial electrolyte for maintaining homeostasis. Most methods measure Pi using ammonium phosphomolybdate under highly acidic conditions. Phospholipid-rich substances, such as liposomal amphotericin B, have been ...
BackgroundInorganic phosphate (Pi) is a crucial electrolyte for maintaining homeostasis. Most methods measure Pi using ammonium phosphomolybdate under highly acidic conditions. Phospholipid-rich substances, such as liposomal amphotericin B, have been ...
Effect of pH on stability and solid phase extraction of urinary free metadrenaline measurement by liquid chromatography tandem mass spectrometry
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundMeasurement of urine free metadrenalines offers potential diagnostic and practical advantages over urinary fractionated metadrenalines in detection of phaeochromocytoma and paraganglioma, including sample collection without acid preservative. ...
BackgroundMeasurement of urine free metadrenalines offers potential diagnostic and practical advantages over urinary fractionated metadrenalines in detection of phaeochromocytoma and paraganglioma, including sample collection without acid preservative. ...
The effect of inadequate drying of blood spots on newborn screening analyte concentrations
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundA critical pre-analytical phase of newborn screening (NBS) testing involves the drying of blood applied to the blood collection devices to form the dried blood spots (DBS). Guidance states that blood applied should be air-dried for a minimum of ...
BackgroundA critical pre-analytical phase of newborn screening (NBS) testing involves the drying of blood applied to the blood collection devices to form the dried blood spots (DBS). Guidance states that blood applied should be air-dried for a minimum of ...
Investigating the effect of icterus interference on a creatinine Roche enzymatic methodology
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundIt is well established that high bilirubin concentrations can lead to erroneous creatinine results when measured by a Jaffe-based method. However, the effects of bilirubin on enzymatic methods appear less well-defined. The Roche Cobas 8000 ...
BackgroundIt is well established that high bilirubin concentrations can lead to erroneous creatinine results when measured by a Jaffe-based method. However, the effects of bilirubin on enzymatic methods appear less well-defined. The Roche Cobas 8000 ...
Performance of the Binding Site cerebrospinal fluid kappa free light chains assay
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundMeasurement of cerebrospinal fluid (CSF) kappa free light chains (KFLCs) for the detection of intrathecal immunoglobulin synthesis has generated interest as an alternative to CSF oligoclonal bands due to its rapid turnaround time and ability to ...
BackgroundMeasurement of cerebrospinal fluid (CSF) kappa free light chains (KFLCs) for the detection of intrathecal immunoglobulin synthesis has generated interest as an alternative to CSF oligoclonal bands due to its rapid turnaround time and ability to ...
Thyroid reference ranges in pregnancy utilizing an Abbott Alinity platform in a multi-ethnic population in the UK
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundMaternal thyroid function significantly affects fetal development. However, thyroid hormone concentrations change dynamically throughout pregnancy rendering non-pregnancy reference ranges inaccurate. We aimed to establish the trimester-, ...
BackgroundMaternal thyroid function significantly affects fetal development. However, thyroid hormone concentrations change dynamically throughout pregnancy rendering non-pregnancy reference ranges inaccurate. We aimed to establish the trimester-, ...
Comparison of three blood collection tubes for 16 biochemical analytes and stability assessment of selected analytes: VACUETTE® CAT serum Sep clot activator tube, VACUETTE® LH lithium heparin Sep tube, and VACUETTE® CAT serum fast separator tube
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundAnalytical performance of VACUETTE® CAT Serum Fast Separator Tube (SFT; Greiner Bio-One, Austria), recently developed quick-clotting serum separator, was evaluated for correlation and stability, comparing with VACUETTE® CAT Serum Sep Clot ...
BackgroundAnalytical performance of VACUETTE® CAT Serum Fast Separator Tube (SFT; Greiner Bio-One, Austria), recently developed quick-clotting serum separator, was evaluated for correlation and stability, comparing with VACUETTE® CAT Serum Sep Clot ...
A five-year retrospective analysis of a national external quality assessment program for urinary organic acid analysis in newborn screening for inherited metabolic disorders in China
Annals of Clinical Biochemistry, Ahead of Print.
ObjectivesUrinary organic acid analysis is crucial for diagnosing inherited metabolic disorders (IMDs). This study assesses the impact of an external quality assessment (EQA) scheme on standardizing urinary organic acid detection in China from 2019 to ...
ObjectivesUrinary organic acid analysis is crucial for diagnosing inherited metabolic disorders (IMDs). This study assesses the impact of an external quality assessment (EQA) scheme on standardizing urinary organic acid detection in China from 2019 to ...