Assay

Rivaroxaban

Key Words

Direct Xa inhibitor, Rivaroxaban

Specimen Collection

3.0ml Citrate (Green lid). 1.4ml Citrate for paediatric (Green lid). Fill to mark. Samples should ideally be received by the laboratory within 3 hours of collection.

Turnaround time

Next working day

Test indications

Rivaroxaban dose monitoring

Interferences

Rivaroxaban levels change markedly over time owing to the pharmacokinetics of the drug (e.g. levels of rivaroxaban will differ greatly 2–4 hours versus 24 hours after dosing). Interpret results with caution. Discuss with Consultant Haematologist if necessary.

Reference Range

See table below. Discuss with Consultant Haematologist if necessary.

Minimum retesting interval

N/A

Dose (mg)

Trough (ng/mL)

Peak (ng/mL)

10mg once daily

1-38

91-195

20mg once daily

4-96

160-360