Coagulation Factor Assay

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Assay

Coagulation Factor Assay

Key Words

Coagulation Factor Assay, Intrinsic Screen, Extrinsic Screen

Specimen Collection

2x 3.0ml Citrate (Green lid). Equivalent volume with 1.4ml Citrate for paediatric (Green lid). Fill to mark. Samples will be processed up to 24 hours from the time of collection. Due to the nature of the assay, this test cannot easily be added on to routine coagulation requests sent with a single sample, UNLESS the assay is being performed on the day of receipt (which only occurs once every two weeks). Contact the laboratory before requesting this test as an add-on.

Turnaround time

2 weeks

Test indications

Investigation of prolonged PT and/or APTT with a personal or family history of bleeding, or as directed by the laboratory.

Interferences

Lipaemia, haemolysis, anticoagulants.

Reference Range

See table below. Adult reference ranges from reagent manufacturer's package inserts. Paediatric reference ranges from: Williams, M., Chalmers, E. and Gibson, B. (2002). The investigation and management of neonatal haemostasis and thrombosis. British Journal of Haematology, 119(2), pp.295-309.

Minimum retesting interval

N/A
TEST AGE / GENDER REFERENCE RANGE UNITS
Factor II Premature, Day 1 20 - 77 IU/dl
Premature, Day 5 29 - 85
Premature, Day 30 36 - 95
Premature, Day 90 30 - 106
Premature, Day 180 51 - 123
Full term, Day 1 37 - 59
Full term 2 - 5 days 48 - 78
Full term at 1 month 51 - 85 
Full term at 3 months 60 - 90
Full term at 6 months 74 - 102
6 months - Adult 79 - 131 
Factor V Premature, Day 1 41 - 144 IU/dl
Premature, Day 5 46 - 154
Premature, Day 30 48 - 156
Premature, Day 90 59 - 139
Premature, Day 180 58 - 146
Full term, Day 1 54 - 90
Full term 2 - 5 days 70 - 120
Full term at 1 month 80 - 116
Full term at 3 months 69 - 111
Full term at 6 months 73 - 109
6 months - Adult 62 - 139
Factor VII Premature, Day 1 21 - 113 IU/dl
Premature, Day 5 30 - 138
Premature, Day 30 21 - 145
Premature, Day 90 31 - 143
Premature, Day 180 47 - 151
Full term, Day 1 47 - 85
Full term 2 - 5 days 62 - 116
Full term at 1 month 66 - 114
Full term at 3 months 65 - 117
Full term at 6 months 67 - 107
6 months - Adult 50 - 129 
Factor VIII Premature, Day 1 50 - 213 IU/dl
Premature, Day 5 53 - 205
Premature, Day 30 50 - 199
Premature, Day 90 58 - 188
Premature, Day 180 50 - 187
Full term, Day 1 61 - 139
Full term 2 - 5 days 55 - 121
Full term at 1 month 58 - 124
Full term at 3 months 56 - 102
Full term at 6 months 55 - 91
6 months - Adult 50 - 150
Factor IX Premature, Day 1 19 - 65 IU/dl
Premature, Day 5 14 - 74
Premature, Day 30 13 - 80
Premature, Day 90 25 - 93
Premature, Day 180 50 - 120
Full term, Day 1 34 - 72 
Full term 2 - 5 days 34 - 72 
Full term at 1 month 36 - 66
Full term at 3 months 44 - 90
Full term at 6 months 61 - 111
6 months - Adult 65 - 150
Factor X Premature, Day 1 11 - 71 IU/dl
Premature, Day 5 19 - 83
Premature, Day 30 20 - 92
Premature, Day 90 35 - 59
Premature, Day 180 35 - 119
Full term, Day 1 26 - 54
Full term 2 - 5 days 34 - 64
Full term at 1 month 45 - 73
Full term at 3 months 53 - 89
Full term at 6 months 58 - 98
6 months - Adult 77 - 131 
Factor XI Premature, Day 1 8 - 52 IU/dl
Premature, Day 5 13 - 69
Premature, Day 30 15 - 71
Premature, Day 90 25 - 93
Premature, Day 180 46 - 110
Full term, Day 1 24 - 52 
Full term 2 - 5 days 39 - 71 
Full term at 1 month 40 - 66 
Full term at 3 months 55 - 83 
Full term at 6 months 62 - 110 
6 months - Adult 65 - 150
Factor XII Premature, Day 1 10 - 66 IU/dl
Premature, Day 5 9 - 69
Premature, Day 30 11 - 75
Premature, Day 90 15 - 107
Premature, Day 180 22 - 142
Full term, Day 1 33 - 73 
Full term 2 - 5 days 29 - 65
Full term at 1 month 33 - 65 
Full term at 3 months 46 - 88
Full term at 6 months 58 - 96
6 months - Adult 50 - 150