Assay

Glucose-6-Phosphate Dehydrogenase (G6PD) Screen

Key Words

Glucose-6-Phosphate Dehydrogenase, G6PD, haemolysis, haemolytic anaemia

Specimen Collection

3.4ml EDTA (Red lid). 1.3ml EDTA for paediatric (Red lid), do not overfill. Carried out on FBC specimen. G6PD screens may be added on to samples that are up to 48 hours old.

Turnaround time

Next working day

Test indications

Haemolytic anaemia, and to assess potential primaquine sensitivity after positive malaria screen.

Please refer to the latest guidelines for Diagnosis of G6PD deficiency at: https://onlinelibrary.wiley.com/doi/10.1111/bjh.16366

Interferences

‘A false normal result can occur in G6PD-deficient individuals with a high reticulocyte count due to an existing acute haemolytic episode.’

‘A false abnormal result can occur in G6PD-normal individuals with severe anaemia.

This G6PD screen cannot reliably detect G6PD deficiency in heterozygous women, therefore samples from females, with normal screening results, will be sent to the reference lab for G6PD assay to confirm

Reference Range

N/A

Minimum retesting interval

N/A