Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundBiotin is commonly used in many commercial assays. It is known that exogenous biotin can interfere with these tests, however, not all manufacturers have issued warnings or reassurances. Interference can lead to increased or decreased ...

Annals of Clinical Biochemistry, Ahead of Print.
Case oneA young woman presented to the Early Pregnancy Assessment Unit (EPAU) with abdominal pain, amenorrhoea and variably positive home-pregnancy tests. On review, a point-of-care test (POCT) for urine beta-HCG (β-HCG) was negative but a blood test ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundHeart failure (HF) is a growing global burden. Although N-terminal pro–B-type natriuretic peptide (NT-proBNP) guides diagnosis, assay cost and analyzer availability limit routine use. Routine laboratory data may offer a low-cost triage ...

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundUrinary C-peptide testing is widely used to evaluate insulin secretion capacity from pancreatic β-cells. We report a case in which urinary C-peptide showed abnormally high levels during treatment with an angiotensin receptor–neprilysin ...

Annals of Clinical Biochemistry, Ahead of Print.
The presence of paraproteins in multiple myeloma can cause analytical interference, resulting in unusual and misleading biochemical outcomes. An uncommon but clinically relevant finding is the reporting of a negative direct bilirubin result on wet ...

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundExposure of plasma to low temperatures induces the conversion of prorenin to renin, causing falsely elevated levels of renin. This also happens at storage temperatures of −20°C. Our survey evaluated the pre-analytical procedures used by clinical ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundBlood glucose concentrations decrease after blood collection. We recently developed novel blood collection tubes containing inosine added to sodium fluoride (NaF; FI tubes), which effectively inhibits post-collection blood glucose decline. ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundThe NHS accounts for approximately 4–5% of England’s total carbon footprint and was the first healthcare organisation to commit to a net-zero target. Reducing the inappropriate use of diagnostic tests could play a meaningful role in reaching ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundFaecal immunochemical tests (FIT) detect and quantify faecal haemoglobin (f-Hb) to triage symptomatic primary care patients for the risk of colorectal cancer (CRC).MethodFIT was performed using FOB Gold® on a Siemens ADVIA Chemistry XPT analyser ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundPneumatic tube systems (PTSs) have revolutionized sample transport efficiency, yet concerns about sample integrity remain unresolved. This study evaluated the AirLab system (PazKorea, Hanam-si, Korea), a novel high-speed carrier-free PTS, for ...

Annals of Clinical Biochemistry, Ahead of Print.
Glycerol kinase deficiency (GKD) is a rare X-linked metabolic disorder often presenting in infancy or childhood. In adults, it may remain undiagnosed due to nonspecific symptoms or incidental biochemical findings. We report a case of incidental GKD ...

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.
Strict homoeostatic control of potassium is necessary for normal muscle and neural function, and as a result, hyperkalaemia can be life-threatening and requires timely management. Prior to treating the patient, however, it is important to determine if ...

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.