Annals of Clinical Biochemistry, Ahead of Print.
Background/ObjectivesThe pre-analytical stability of electrolytes in capped whole blood at room temperature remains uncertain due to limited studies and inconsistent findings. This study investigates electrolyte stability during delayed centrifugation, in ...

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundCerebrospinal fluid (CSF) spectrophotometry is well-established in the UK for measuring CSF bilirubin and oxyhaemoglobin to aid in the diagnosis of subarachnoid haemorrhage. Although it is known that some antibiotics and large amounts of ...

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.
ContextSclerostin inhibits bone formation via the WNT/β-catenin pathway and is a therapeutic target in osteoporosis. Antibodies against sclerostin are currently under investigation for the treatment of osteogenesis imperfecta (OI), a rare, genetically and ...

Annals of Clinical Biochemistry, Ahead of Print.
The homeostatic model assessment for insulin resistance (HOMA-IR) is one of the most commonly applied surrogate markers for the measurement of insulin resistance; however, the use of this metric does require sex-specific, age-specific, and body mass index ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundStatistical quality control continues to serve as the cornerstone for ensuring the accuracy and reliability of laboratory investigations. The current research aimed to evaluate the performance of biochemistry parameters using Six Sigma metrics ...

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.
Cryoglobulins are proteins that are temperature sensitive, precipitating at temperatures below 37°C, and dissolve upon rewarming. However, at lower temperatures cryoglobulins can result in damage subsequently leading to vascular compromise. We present a ...

Annals of Clinical Biochemistry, Ahead of Print.
B-type natriuretic peptide (BNP) is crucial for heart failure diagnosis. However, immunoassays are vulnerable to heterophilic antibody interference, which may lead to false-positive results and significant clinical mismanagement. Studies suggest such ...

Annals of Clinical Biochemistry, Ahead of Print.
Venepuncture is traditionally regarded as the gold standard for collecting blood samples. However, self-collected capillary blood sampling has emerged as a practical alternative in various settings, fostering a more patient-centred, personalised, and cost-...

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.
A 37-year-old woman attended hospital with melaena and coffee-ground vomiting on a background of alcohol-related liver disease (ALD). Following upper gastro-intestinal (GI) endoscopy she was admitted to the medical high dependency unit and commenced on ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundAlbuminuria is an early marker of kidney damage and an essential component of chronic kidney disease (CKD) risk stratification. Quantitative measurement of the urine albumin-to-creatinine ratio (ACR) in a spot, preferably morning, urine sample ...

Annals of Clinical Biochemistry, Ahead of Print.
ObjectivesThe objective of this study was to develop deep learning models for the automated classification of serum protein electrophoresis (SPE) and immunofixation electrophoresis (IFE) images into oncologic, non-oncologic, and healthy categories, and to ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundArtificial intelligence (AI) is increasingly recognized as transformative in laboratory medicine, yet adoption lags behind radiology and cardiology. Limited data exist on AI-related attitudes and perceived barriers in Turkish clinical ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundA growing body of evidence suggests that male infertility is a precursor to future health problems. This study aimed to develop a unique circulating biomarker that could contribute to the diagnosis of male infertility.Materials and methodsThe ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundSample stability represents a major challenge in the preanalytical phase of urinalysis. This study aimed to evaluate and compare the stability of urine samples stored at room temperature for up to 72 h in two commercially available chlorhexidine-...