Annals of Clinical Biochemistry, Ahead of Print.
Cryoglobulins are proteins that are temperature sensitive, precipitating at temperatures below 37°C, and dissolve upon rewarming. However, at lower temperatures cryoglobulins can result in damage subsequently leading to vascular compromise. We present a ...

Annals of Clinical Biochemistry, Ahead of Print.
B-type natriuretic peptide (BNP) is crucial for heart failure diagnosis. However, immunoassays are vulnerable to heterophilic antibody interference, which may lead to false-positive results and significant clinical mismanagement. Studies suggest such ...

Annals of Clinical Biochemistry, Ahead of Print.
Venepuncture is traditionally regarded as the gold standard for collecting blood samples. However, self-collected capillary blood sampling has emerged as a practical alternative in various settings, fostering a more patient-centred, personalised, and cost-...

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.
A 37-year-old woman attended hospital with melaena and coffee-ground vomiting on a background of alcohol-related liver disease (ALD). Following upper gastro-intestinal (GI) endoscopy she was admitted to the medical high dependency unit and commenced on ...

Annals of Clinical Biochemistry, Ahead of Print.
ObjectivesThe objective of this study was to develop deep learning models for the automated classification of serum protein electrophoresis (SPE) and immunofixation electrophoresis (IFE) images into oncologic, non-oncologic, and healthy categories, and to ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundArtificial intelligence (AI) is increasingly recognized as transformative in laboratory medicine, yet adoption lags behind radiology and cardiology. Limited data exist on AI-related attitudes and perceived barriers in Turkish clinical ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundA growing body of evidence suggests that male infertility is a precursor to future health problems. This study aimed to develop a unique circulating biomarker that could contribute to the diagnosis of male infertility.Materials and methodsThe ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundSample stability represents a major challenge in the preanalytical phase of urinalysis. This study aimed to evaluate and compare the stability of urine samples stored at room temperature for up to 72 h in two commercially available chlorhexidine-...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundCapillary blood collection offers a less burdensome alternative to venous sampling and may improve access to laboratory testing in resource-limited settings. However, manual procedures can yield pre-analytical variation, resulting in the need ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundTotal protein (TP) is a key indicator to differentiate between pleural effusion (PE) and ascites as exudate or transudate. Rapid quantification of TP can provide more accurate clinical treatment.ObjectiveThis study developed a smartphone-based ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundChronic kidney disease (CKD) prevalence and prognosis are currently based exclusively on glomerular functions, but the kidney tubule possesses numerous additional functions with pathophysiological and prognostic value. Tubular secretion is also ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundThe significance level specified for a statistical analysis indicates the expected false positive rate. Failure to confine false positives to their expected rates can lead to misleading conclusions and especially in studies investigating ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundVitamin B12 deficiency can cause anaemia, fatigue, and neurological sequelae. Total B12 assays may not be reflective of tissue B12. Methylmalonic acid (MMA) can assess tissue B12 more accurately. NICE published clinical guidelines on Vitamin B12 ...

Annals of Clinical Biochemistry, Ahead of Print.
IntroductionWhile conclusions regarding the effects of serum separator tubes on some laboratory tests have been reached in previous studies, the effects of these tubes on the B12 test have not been adequately investigated. This study aimed to determine ...

Annals of Clinical Biochemistry, Ahead of Print.

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundBiotin is commonly used in many commercial assays. It is known that exogenous biotin can interfere with these tests, however, not all manufacturers have issued warnings or reassurances. Interference can lead to increased or decreased ...

Annals of Clinical Biochemistry, Ahead of Print.
Case oneA young woman presented to the Early Pregnancy Assessment Unit (EPAU) with abdominal pain, amenorrhoea and variably positive home-pregnancy tests. On review, a point-of-care test (POCT) for urine beta-HCG (β-HCG) was negative but a blood test ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundHeart failure (HF) is a growing global burden. Although N-terminal pro–B-type natriuretic peptide (NT-proBNP) guides diagnosis, assay cost and analyzer availability limit routine use. Routine laboratory data may offer a low-cost triage ...