Zinc Transporter 8 antibodies
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Assay |
Zinc Transporter 8 antibodies |
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Key Words |
Zinc Transporter 8 Ab's, ZNT8 |
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Specimen Collection |
Serum (Brown) |
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Turnaround time |
10 days
This test is referred to another centre: Protein Reference Unit & Immunology Department 0114 2715552
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Test indications |
Zinc transporter 8 (ZnT8) is an islet beta cell secretory granule membrane protein that has been identified as an autoantibodies antigen in type 1 diabetes. ZnT8 antibodies can be used in addition to the other diabetic markers : GAD 65 antibodies, IA-2 antibodies and islet cell antibodies to differentiate clinical phenotypes.
Positive GAD65 antibodies , IA-2 antibodies and ZnT8 antibodies in combination are associated with younger age onset of autoimmune diabetes and more severe insulin deficiency. ZnT8 antibodies can be seen in up to 80% of new type 1 diabetes cases and in up to 26% of type 1 diabetes patients that are negative for GAD65 antibodies, IA-2 antibodies, islet cell antibodies and insulin antibodies. The antibodies generally appear later than GAD65 antibodies and insulin antibodies, although not in a strict order.
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Methodology |
ELISA |
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Interferences |
Contact referral lab |
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Reference Range |
Negative 0-14 RU/mL
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Analytical error |
Contact referral lab |
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Reference change value |
Contact referral lab |
