Adrenal Cortical Antibodies
|
Assay |
Adrenal cortical antibodies |
|
Key Words |
Adrenal cortical antibodies, adrenal antibodies (ADRA) |
|
Specimen Collection |
Serum (brown) |
|
Turnaround time |
10 days This test is referred to another centre: Department of Clinical Chemistry and Immunology Level 4 |
|
Test indications |
Anti-adrenal antibodies are found in 60% of patients with idiopathic hypoadrenalism where they are directed against the enzyme 21-hydroxylase, and in 90% of those with hypoadrenalism in association with ovarian failure (Autoimmune Polyglandular Syndrome-1, APS-1) where they react with 17-hydroxylase and the side chain cleaving enzyme complex involved in steroid bio-synthesis. They are found in <0.1% of the normal population. The titre of antibody is of no significance, and so is not measured. As the adrenal gland atrophies the antibodies may disappear so sequential follow-up is not useful. |
|
Methodology |
Indirect immunofluorescence |
|
Interferences |
Contact referral laboratory |
|
Reference Range |
Contact referral laboratory |
|
Analytical error |
N/A |
|
Reference change value |
N/A |
