Used in the investigation of calcium and/or phosphate metabolism. Hypoparathyroidism, vitamin D intoxication and renal failure with decreased glomerular phosphate filtration give rise to hyperphosphataemia. Hypophosphataemia occurs in rickets, hyperparathyroidism and Fanconis syndrome.
Phospholipids contained in liposomal drug formulations (e.g. AmBisome) may be hydrolysed in the test due to the acidic reaction pH and thus lead to elevated phosphate results.
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