Assay

Scleroderma antibodies

Key Words

Scleroderma antibodies

Specimen Collection

Serum (Brown)

Turnaround time

14 days

This test is referred to another centre:

Department of Clinical Chemistry and Immunology

Level 4

Addenbrooke’s Hospital NHS Trust

Hills Road

Cambridge

CB2 2QQ

01223 217215

Test indications

Scl-70, CENP A, CENP B, RP11, RP155, Fibrillarin, NOR90, Th/To, PM-Scl100, PM-Scl75, Ku, PDGFR and Ro-52 are scleroderma specific and/or associated antibodies which can be tested for by immunoblotting if specifically requested on clinical grounds, or as a follow up investigation.

RNA polymerase 3 and fibrillarin have a high specificity for systemic sclerosis.

Th/To antibodies are found in patients with systemic sclerosis, predominantly the limited cutaneous form but also with Primary Raynaud’s , SLE, polymyositis and RA.

NOR90 (Nucleolar Organising Region 90) antibodies are rare and are associated with patients with Scleroderma and Raynaud’s phenomenon.

Methodology

Immunoblot

Interferences

Contact referral lab

Reference Range

Contact referral lab

Analytical error

Contact referral lab

Reference change value

Contact referral lab