Assay

Ovarian antibodies

Key Words

Ovarian antibodies

Specimen Collection

Serum (brown)

Turnaround time

14 days

This test is referred to another centre:                                                                                         

Department of Clinical Chemistry and Immunology                                                                                                                  

Addenbrookes Hospital NHS Trust

Hills Road
Cambridge CB2 2QQ
Tel: 01223 217215
Fax: 01223 217794

Test indications

These antibodies are found in 15-50% of patients with premature ovarian failure under the age of 40 years. These antibodies react with steroid producing cells and thus also stain the steroid producing Leydig cells of the testis, the placenta and often also in the adrenal cortex. They are often seen in Autoimmune Polyglandular Syndrome-1 (APS-1) where adrenal and ovarian failure may co-exist. Up to 70% of women may have transient anti-ovarian antibodies during IVF therapy. Patients with APS-1 have mutations in the Autoimmune Regulator (AIRE) gene.

Methodology

Indirect immunofluorescence

Interferences

Contact referral centre

Reference Range

N/A

Analytical error

Contact referral centre

Reference change value

N/A