Assay

Apixaban

Key Words

Direct Xa inhibitor, Apixaban

Specimen Collection

3.0ml Citrate (Green lid). 1.4ml Citrate for paediatric (Green lid). Fill to mark. Samples shoule ideally be received by the laboratory within 3 hours of collection.

Turnaround time

Next working day

Test indications

Apixaban dose monitoring

Interferences

Apixaban levels change markedly over time owing to the pharmacokinetics of the drug (e.g. levels of apixaban will differ greatly 2–4 hours versus 12 hours after dosing). Interpret results with caution. Discuss with Consultant Haematologist if necessary.

Reference Range

See table below. Discuss with Consultant Haematologist if necessary.

Minimum retesting interval

N/A

Dose (mg)

Trough (ng/mL)

Peak (ng/mL)

2.5,g twice daily

20-94

36-100

10mg twice daily

31-412

122-412