Assay

Factor XIII Antigen Assay

Key Words

Factor XIII Antigen

Specimen Collection

2x 3.0ml Citrate (Green lid). Equivalent volume with 1.4ml Citrate for paediatric (Green lid). Fill to mark. Samples will be processed up to 24 hours from the time of collection. Due to the nature of the assay, this test cannot easily be added on to routine coagulation requests sent with a single sample, UNLESS the assay is being performed on the day of receipt (which only occurs once every two weeks). Contact the laboratory before requesting this test as an add-on.

Turnaround time

2 weeks

Test indications

Suspected congenital or acquired Factor XIII deficiency: Persistent and delayed bleeding from umbilical stump, bleeding in soft tissues, CNS, muscle, or into/around joints

Interferences

Hyperbilirubinaemia, haemolysis, hyperlipidaemia.

Reference Range

See table. Adult reference ranges from reagent manufacturer's package inserts. Paediatric reference ranges from: Williams, M., Chalmers, E. and Gibson, B. (2002). The investigation and management of neonatal haemostasis and thrombosis. British Journal of Haematology, 119(2), pp.295-309.  

Minimum retesting interval

N/A

AGE

REFERENCE RANGE

UNITS

Full term 1 day

53 – 99

 IU/dl

5 days old - Adult

75.2 – 154.8

 IU/dl

Healthy PREMATURE neonate (30 – 36 weeks gestation)

Day 1

32 – 108

 IU/dl