Assay

Glomerular basement membrane (GBM) antibodies

Key Words

Glomerular basement membrane antibodies, GBM

 Specimen Collection

Serum (brown)

If this assay is needed URGENTLY please call the laboratory on x8454 to discuss

Turnaround time

7 days

Test indications

Antibodies against type IV collagen are seen in Goodpasture’s syndrome, a pulmonary-renal form of vasculitis associated with rapidly progressing renal failure and haemoptysis. About 10% of patients with Wegener’s granulomatosis may also have GBM antibodies.

Methodology

Enzyme immunoassay

Interferences

No known methodological interferences

Reference Range

Negative  <7 U/mL

Equivocal 7-10 U/mL

Positive    >10 U/mL

Analytical error

Contact laboratory (x8454)

Reference change value

N/A