Assay

Ganglioside antibodies

Key Words

Ganglioside GM1 antibodies (GM1), Ganglioside GQ1B antibodies (GQ1B)

Specimen Collection

Serum (brown)

Turnaround time

14 days                                                                                                                                                                   

 This test is referred to another centre:                                                                                                                            

Neuroimmunology & CSF laboratory

(Box 76) 9th Floor

UCL Queen Square Institute of Neurology

Queen Square 

London 

WC1N 3BG 

Telephone : 020 3448 3812 

Test indications

These antibodies are associated with the following neurological diseases: 

• IgM anti-GM1 antibodies are associated with acquired motor neuropathies and are found in over 50% of cases.
• IgG anti-GM1 antibodies -although these may be found in a small proportion (5 – 15%) of patients with Guillain-Barré syndrome, their measurement adds little to diagnosis or management.
• IgG anti-GQ1b antibodies are found in over 90% of patients with Miller-Fisher syndrome.
• IgM anti-GQ1b antibodies are associated with a minority of patients with of chronic ataxic sensory neuropathy.

Methodology

Contact referral centre

Interferences

Contact referral centre

Reference Range

N/A

Analytical error

Contact referral centre

Reference change value

N/A