Apixaban
Assay |
Apixaban |
Key Words |
Direct Xa inhibitor, Apixaban |
Specimen Collection |
3.0ml Citrate (Green lid). 1.4ml Citrate for paediatric (Green lid). Fill to mark. Samples shoule ideally be received by the laboratory within 3 hours of collection. |
Turnaround time |
Next working day |
Test indications |
Apixaban dose monitoring |
Interferences |
Apixaban levels change markedly over time owing to the pharmacokinetics of the drug (e.g. levels of apixaban will differ greatly 2–4 hours versus 12 hours after dosing). Interpret results with caution. Discuss with Consultant Haematologist if necessary. |
Reference Range |
See table below. Discuss with Consultant Haematologist if necessary. |
Minimum retesting interval |
N/A |
Dose (mg) |
Trough (ng/mL) |
Peak (ng/mL) |
2.5,g twice daily
|
20-94 |
36-100 |
10mg twice daily
|
31-412 |
122-412 |
Gosselin RC, Adcock DM. The laboratory’s 2015 perspective on direct oral anticoagulant testing. J Thromb Haemost 2016; 14: 886-93.