von Willebrand Factor (vWF) and Collagen Binding Assay

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von Willebrand Factor (vWF) and Collagen Binding Assay

Key Words

von Willebrand Factor, vWF, Factor 8, FVIII, Collagen, Binding, CBA

Specimen Collection

2x 3.0ml Citrate (Green lid). Equivalent volume with 1.4ml Citrate for paediatric (Green lid). Fill to mark. Samples will be processed up to 24 hours from the time of collection. Due to the nature of the assay, this test cannot easily be added on to routine coagulation requests sent with a single sample, UNLESS the assay is being performed on the day of receipt (which only occurs once every two weeks). Contact the laboratory before requesting this test as an add-on.

Turnaround time

2 weeks

Test indications

Family history of von Willebrand Disease, investigation of bleeding tendency (factor 8 levels will also be tested).


Lipaemia, haemolysis, pregnancy, stress, infection and inflammation. The presence of Rheumatoid Factor may produce an overestimation of the vWF antigen test result.

Reference Range

See table below. Adult reference ranges from reagent manufacturer's package inserts.

Minimum retesting interval


Test Range
von Willebrand Factor Antigen 42 - 141 IU/dl
von Willebrand Factor Ristocetin Cofactor Activity 48 - 202 IU/dl
Collagen Binding Assay 47 - 170 IU/dl