Full Blood Count (FBC)

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Assay

Full Blood Count (FBC)

Key Words

Full Blood Count, FBC, SFBC

Specimen Collection

3.4ml EDTA for adults, and where possible, for children >10 years old (Red lid); 1.3ml EDTA for paediatric patients <10 years old (Red lid), do not overfill. If a Kleihauer is also requested, an additional sample bottle is required. If a paediatric ESR is also requested, an additional paediatric 1.3ml EDTA sample bottle is required. These two tests cannot be run from the same sample as the FBC. FBC tests may be added on to samples that are up to 48 hours old, but some sequential tests may not be possible at this point - samples should ideally be less than 24 hours old.

Turnaround time

Next working day

Test indications

Investigations of red cells, white cells and platelets

Interferences

Lipaemia causes a falsely elevated haemoglobin which also affects MCV and MCHC - If the lipaemia is identified during analysis due to these indices being significantly abnormal, then laboratory staff will perform a hyperlipidaemia correction to return the Hb, MCV and MCHC to their true values. Hyperbilirubinaemia does not affect the haemoglobin value but may affect other FBC values. Clots or fibrin strands in samples, platelet aggregates, and/or haemolysis can irreparably damage cellular content in the sample and render most FBC parameters invalid - Samples will be either processed with a disclaimer, processed with the most affected FBC values removed, or rejected entirely depending on the severity of the sample degradation. Samples identified by the laboratory as containing cryoglobulins will be warmed prior to analysis to minimise red cell clumping and the subsequent effect on the FBC results.

Reference Range

See table below. Reference ranges for FBC parameters obtained from Phase II of the Pathology Harmonisation Project.

Minimum retesting interval

N/A

TEST AGE/GENDER RANGE UNITS
Haemoglobin (Hb) Up to 1 day 150-236 g/L
1 - 14 days 128-218
14 days - 4 weeks 101-183
4  - 36 weeks 100-140
36 weeks - 1 year 113-141
1 - 12 years 110-151
Males over 12 years 130-180
Females over 12 years 115-165
Pregnant 100-150
Red Blood Cell Count (RBC) Up to 1 day 3.77-6.51 1012/L
1-14 days 3.0-5.2
14 days - 4 weeks 2.8-5.2
4 weeks - 1 year 3.3-5.5
1 - 12 years 3.5-5.5
Males over 12 years 4.4-6.5
Females over 12 years 3.8-5.8
Pregnant 3.5-5.0
Haematocrit (HCT)  Up to 1 day 0.45-0.67 Ratio
1 day - 4 weeks 0.31-0.55
4 weeks - 1 year 0.33-0.39
1 - 12 years 0.33-0.43
Males over 12 years 0.4-0.53
Females over 12 years 0.36-0.46
Pregnant 0.32-0.46
Mean Cell Volume (MCV) Up to 1 day 101-137 fL
1-14 days 85-140
14 days - 4 weeks 90-120
4 weeks - 1 year 70-90
1 - 12 years 73-90
over 12 years 80-100
Mean Cell Haemoglobin (MCH) Up to 1 day 31-37 pg
1 day - 4 weeks 28-40
4 weeks - 1 year 23-31
1 - 12 years 25-33
over 12 years 27-33
Mean Cell Haemoglobin Concentration (MCHC) ALL 318-364 g/L
Red cell Distribution Width (RDW) Up to 1 day 11.0-17.0 %
1-14 days 11.0-17.0
over 14 days 11.5-15.0
Platelet Count (PLT) ALL 150-400 109/L
Mean Platelet Volume (MPV) ALL 9-12.1 fL
White Blood Cell Count (WBC) Up to 1 day 9.4-34 109/L
1 days - 4 weeks 5-19.5
4 weeks - 1 year 6-17.5
1 - 12 years 4.5-13.5
over 12 years 4.0-11
Pregnant 4.0-15
Neutrophil Count Up to 1 day 1.7-19 109/L
1 day - 4 weeks 1.5-10
4 weeks - 1 year 1.0-9
1 - 12 years 1.5-8.5
over 12 years 1.8-7.7
Lymphocyte Count Up to 1 day 1.5-11.5 109/L
1 day - 4 weeks 1.5-16
4 weeks - 1 year 2-11.5
1 - 12 years 1.5-5
over 12 years 1.4-4.8
Monocyte Count Up to 1 day 0.1-3.7 109/L
1 day - 4 weeks 0.1-2
4 weeks - 1 year 0.1-1
1 - 12 years 0.1-0.8
over 12 years 0.1-0.8
Eosinophil Count Up to 1 day 0-2 109/L
1 day - 4 weeks 0-1
4 weeks - 1 year 0.1-0.6
1 - 12 years 0.1-0.6
over 12 years 0.1-0.6
Basophil Count All <0.1 109/L